International Fragrance Association International Fragrance Association Annual Report 2025
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Chapter 03 · Science and regulation

New approach methodologies (NAMs)

Two interviews1 min read
Watch the interviewWatched Amaia IrizarYouTube
  • Amaia IrizarSenior Toxicology Associate

Interview 1 of 2

Shifting toward animal-free safety assessment

A global move to new approach methodologies

Amaia Irizar, Senior Toxicology Associate at IFRA, outlines the regulatory developments of 2025 that signal a global transition toward animal-free chemical safety assessment. Authorities in the EU, the United States, Canada and the United Kingdom advanced strategies and roadmaps that promote New Approach Methodologies (NAMs) and phase out vertebrate testing.

These initiatives will directly affect the fragrance industry, clarifying how evidence based on NAMs can be used in regulatory submissions and reducing reliance on animal testing. The shift opens the way to greater global alignment, but coordination will be essential to avoid fragmented requirements. In 2026, IFRA will support implementation, including through its active role in the European Partnership for Alternative Approaches to Animal Testing.

Watch the interviewWatched Amaia IrizarYouTube
  • Amaia IrizarSenior Toxicology Associate

Interview 2 of 2

IDEA: progress toward animal-free risk assessment

Quantitative risk assessment for skin sensitization based only on NAMs

Amaia Irizar highlights the progress made in 2025 under the International Dialogue for the Evaluation of Allergens (IDEA). The multi-stakeholder initiative continued to advance science-based risk assessment for skin sensitization, supporting the safe use of fragrance ingredients within defined exposure limits.

A key milestone was the extension of the IDEA Reference Chemical Potency List to 110 substances. Now published in a peer-reviewed journal, the List supports the use of quantitative New Approach Methodologies (NAMs) in a follow-up IDEA study. Findings were shared with regulators, scientific bodies and experts through workshops and consultations.

In 2026, IDEA will continue its dissemination and outreach, a significant step toward fully NAM-based quantitative risk assessment that maintains strong consumer protection.

Up next · Chapter 03

IDEA project

Two interviews, starting with ‘Stakeholder engagement and the IDEA project’.

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