A global paradigm shift in chemical testing guidelines has been observed, recognizing the limitations of animal testing and the growing preference for New Approach methodologies (NAMs). In 2024, there was a milestone Achieved in the use of NAMs.
In 2024, IFRA’s consortium addressed inhalation safety concerns for Acetylated Vetiver Oil (AVO), a key fine fragrance ingredient. Using a New Approach Methodology (NAM), they presented experimental data to the SCCS, which issued a positive opinion supporting AVO’s safety in sprayable applications.
This marked a milestone as it was the first use of a NAM in vitro method for this endpoint on a complex fragrance ingredient. In 2025, the consortium will publish findings to guide future safety assessments.